4Dimethylaminoazobenzene [factsheet]

4-DIMETHYLAMINOAZOBENZENE

Please Note: The main source of information for this fact sheet is the Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature. Other secondary sources include the International Agency for Research on Cancer (IARC) monographs on chemicals carcinogenic to man and the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed.

Environmental/Occupational Exposure

* Occupational exposure (primarily dermal) may occur for those workers who manufacture or use azo dyes. (1)

Assessing Personal Exposure

* No information is available on the assessment of personal exposure to 4-dimethyl-aminoazobenzene.

Health Hazard Information

Acute Effects:

* Contact dermatitis has been observed in workers who handled 4-dimethylaminoazobenzene. (1)

* Tests involving acute exposure of animals,, such as the LD₅₀ test in rats, have shown 4-dimethylaminoazobenzene to have high acute toxicity from oral exposure. (2)

Chronic Effects (Noncancer):

* No information is available on the chronic (long-term) effects of 4-dimethylaminoazobenzene in humans or animals.

* EPA has not established an RfC or an RfD for 4-dimethylaminoazobenzene. (3)

Reproductive/Developmental Effects:

* No information is available on the reproductive or developmental effects of 4-di-methylaminoazobenzene in humans.

* Animal studies have reported birth defects in the offspring of mice exposed to 4-di-methylaminoazobenzene. (1)

Cancer Risk:

* No information is available on the carcinogenic effects of 4-dimethylaminoazobenzene in humans.

* Animal studies have reported tumors of the liver and bladder from oral exposure to 4-dimethylaminoazobenzene. (1,4,5)

* EPA has classified 4-dimethylaminoazobenzene as a Group B2, probable human carcinogen. (1)

Physical Properties

* 4-Dimethylaminoazobenzene exists as yellowish, crystalline leaflets. (1)

* The chemical formula for 4-dimethylaminoazobenzene is C₁₄H₁₅N₃, and the molecular weight is 225.3 g/mol. (1)

* The vapor pressure for 4-dimethylaminoazobenzene is 3.3 H 10^-7 mm Hg at 25 EC, and it has a log octanol/water partition coefficient (Log K_ow) of 4.58. (1)

Uses

* 4-Dimethylaminoazobenzene is used for coloring polishes and other wax products, polystyrene, soap, and as an indicator. (4)

Note: There are very few health numbers or regulatory/advisory numbers for 4-dimethylaminoazobenzene; thus, a graph has not been prepared for this compound.

References

1. U.S. Department of Health and Human Services. Hazardous Substances Data Bank (HSDB, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.

2. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.

3. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on 4-Dimethylaminoazobenzene. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1993.

4. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Volume 8. World Health Organization, Lyon. 1975.

5. M. Sittig. Handbook of Toxic and Hazardous Chemicals and Carcinogens. 2nd ed. Noyes Publications, Park Ridge, NJ. 1985.