4Nitrobiphenyl [factsheet]

4-NITROBIPHENYL

Please Note: The main sources of information for this fact sheet are the Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature and the IARC monographs on chemicals. Other secondary sources include the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed, and the Handbook of Toxic and Hazardous Chemicals and Carcinogens.

Environmental/Occupational Exposure

* Since 4-nitrobiphenyl is no longer manufactured or used in the United States, the only exposure to the chemical is from hazardous waste which was disposed of in past years. (1)

Assessing Personal Exposure

* No information is available on the assessment of personal exposure to 4-nitrobiphenyl.

Health Hazard Information

Acute Effects:

* 4-Nitrobiphenyl irritates the eyes, mucous membranes, and respiratory tract from acute (short-term) exposure in humans. Other effects from acute exposure include headache, nausea, vomiting, and fatigue. (1)

* Tests involving acute exposure of animals, such as the LD₅₀ test in rats and rabbits, have shown 4-nitrobiphenyl to have moderate acute toxicity from oral exposure. (2)

Chronic Effects (Noncancer):

* Workers chronically (long-term) exposed to high concentrations of 4-nitrobiphenyl have reported effects on the peripheral and central nervous systems and the liver and kidney. (1)

* No information is available on the chronic effects of 4-nitrobiphenyl in animals.

* EPA has not established an RfD for nitrobiphenyl. (3)

* The RfC for 4-nitrobiphenyl is under review by EPA. (3)

Reproductive/Developmental Effects:

* No information is available on the reproductive or developmental effects of 4-nitrobiphenyl in humans or animals.

Cancer Risk:

* No information is available on the carcinogenic effects of 4-nitrobiphenyl in humans. However, 4-nitrobiphenyl has been used in the production of 4-aminobiphenyl, which is a known human bladder carcinogen. (1,4)

* In one animal study, oral exposure to 4-nitrobiphenyl resulted in bladder tumors. (1,4)

* EPA has not classified 4-nitrobiphenyl for carcinogenicity.

* IARC has classified 4-nitrobiphenyl as a Group 3; the chemical is not classifiable as to its carcinogenicity to humans. (4)

Physical Properties

* 4-Nitrobiphenyl exists as yellow or white needles with a sweetish odor. (5)

* The chemical formula for 4-nitrobiphenyl is C₁₂H₉NO₂, and the molecular weight is 199.22 g/mol. (5)

* The log octanol/water partition coefficient (Log K_ow) for 4-nitrobiphenyl is 3.77. (5)

Uses

* 4-Nitrobiphenyl is not manufactured, imported, used, or sold in the United States at the present time. (1)

Note: There are very few health numbers or regulatory/advisory numbers for 4-nitrobiphenyl; thus, a graph has not been prepared for this compound.

References

1. U.S. Department of Health and Human Services. Hazardous Substances Data Bank (HSDB, online database). National Toxicology Information Program, Bethesda, National Library of Medicine, MD. 1993.

2. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.

3. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on 4-Nitrobiphenyl. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1993.

4. International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Volume 4. World Health Organization, Lyon. 1974.

5. M. Sittig. Handbook of Toxic and Hazardous Chemicals and Carcinogens. 2nd ed. Noyes Publications, Park Ridge, NJ. 1985.